Confined placental mosaicism: implications for fetal chromosomal analysis using microarray comparative genomic hybridization

نویسندگان

  • Evangelia Karampetsou
  • Deborah Morrogh
  • Terry Ballard
  • Jonathan J Waters
  • Nicholas Lench
  • Lyn S Chitty
چکیده

NE Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK TDL Genetics, The Doctors Laboratory, London, UK UCL Institute of Child Health, London, UK University College Hospital NHS Foundation Trust, London, UK Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK *Correspondence to: Lyn S. Chitty. E-mail: [email protected] The copyright line in this article was changed on 22 August 2014 after online publication.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comment on 'confined placental mosaicism: implications for fetal chromosomal analysis using microarray comparative genomic hybridization'.

NE Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK TDL Genetics, The Doctors Laboratory, London, UK UCL Institute of Child Health, London, UK University College Hospital NHS Foundation Trust, London, UK Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK *Correspondence to: Lyn S. Chitty. E-mail: [email protected]...

متن کامل

Chromosomal Mosaicism in Human Feto-Placental Development: Implications for Prenatal Diagnosis

Chromosomal mosaicism is one of the primary interpretative issues in prenatal diagnosis. In this review, the mechanisms underlying feto-placental chromosomal mosaicism are presented. Based on the substantial retrospective diagnostic experience with chorionic villi samples (CVS) of a prenatal diagnosis laboratory the following items are discussed: (i) The frequency of the different types of mosa...

متن کامل

Chromosomal mosaicism confined to the placenta in human conceptions.

Placental and fetal tissues from 46 human pregnancies were cultured and cytogenetically analyzed in an attempt to document the existence of chromosomal mosaicism confined strictly to tissues of extraembryonic origin. In two gestations in which chromosomal mosaicism was found, it was expressed exclusively in placental chorionic cells and was not detected in cells derived from the embryo proper. ...

متن کامل

Confined placental mosaicism.

In most pregnancies the chromosomal complement detected in the fetus is also present in the placenta. The detection of an identical chromosomal complement in both the fetus and its placenta has always been expected as both develop from the same zygote. However, in approximately 2% of viable pregnancies studied by chorionic villus sampling (CVS) at 9 to 11 weeks of gestation, the cytogenetic abn...

متن کامل

Evidence for feasibility of fetal trophoblastic cell‐based noninvasive prenatal testing†

OBJECTIVE The goal was to develop methods for detection of chromosomal and subchromosomal abnormalities in fetal cells in the mother's circulation at 10-16 weeks' gestation using analysis by array comparative genomic hybridization (CGH) and/or next-generation sequencing (NGS). METHOD Nucleated cells from 30 mL of blood collected at 10-16 weeks' gestation were separated from red cells by densi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 34  شماره 

صفحات  -

تاریخ انتشار 2014